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Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
Published on: April 19, 2017
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Engineering immunity via skin-directed drug delivery devices
Suryanarayana Polaka1, Vaishali Makwana1, Nupur Vasdev1
1National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opp. Air force station, Gandhinagar 382355, Gujarat, India.
Summary
Developing effective skin vaccine delivery systems is crucial for combating infectious diseases. This review explores advanced vehicles for intracutaneous delivery to enhance immune responses and overcome translation challenges.
Area of Science:
- Immunology and vaccine development
- Biotechnology and nanomedicine
- Dermatology and skin science
Background:
- Significant research focuses on developing safe and effective vehicles for targeted vaccine delivery to the skin.
- Current vaccine translation from research to clinical application remains a challenge, necessitating consideration of safety, efficacy, and scalability.
- Advancements in nanoscience and bioengineering support vaccine adjuvant development, but practical implementation requires addressing multifaceted concerns.
Purpose of the Study:
- To provide comprehensive insights into skin immunization strategies and vaccine delivery systems.
- To review various platforms engineered for intracutaneous vaccine delivery and their potential for modulating immunity.
- To highlight the importance of a well-designed vaccine delivery program for successful market translation.
Main Methods:
- Review of existing literature on skin immunization approaches, including mucosal vaccines and immunological responses.
- Discussion of various vaccine delivery systems such as nanoparticles, liposomes, and microneedles.
- Analysis of antigen-adjuvant combinations and their role in immune modulation.
Main Results:
- Skin immunization offers a promising route for achieving systemic cellular and humoral responses against infectious diseases.
- Diverse delivery systems, including microparticles, nanoparticles, and microneedles, have been explored for engineering skin immunization.
- The review synthesizes information on the efficacy and application of various vaccine delivery platforms.
Conclusions:
- Developing fit-to-purpose vehicles for in-situ intracutaneous vaccine delivery is key to overcoming current limitations.
- Addressing safety, efficacy, scalability, and regulatory aspects is vital for successful vaccine translation.
- This review offers valuable insights for researchers developing next-generation intracutaneous vaccine delivery systems.
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