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Induced Pluripotent Stem Cells and Hormesis.

Edward J Calabrese1

  • 1Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.

Dose-Response : a Publication of International Hormesis Society
|March 14, 2022
PubMed
Summary
This summary is machine-generated.

This study is the first to examine agent-induced hormetic dose responses in induced pluripotent stem cells. It explores the mechanisms and therapeutic potential of these responses across various cell types.

Keywords:
biphasic dose responsecell differentiationcell proliferationhormesisinduced pluripotent stem cells

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Area of Science:

  • Stem cell biology
  • Toxicology
  • Pharmacology

Background:

  • Hormesis, a dose-response phenomenon, is observed across biological systems.
  • Induced pluripotent stem cells (iPSCs) offer a model for studying cellular responses.
  • Understanding agent-induced effects on stem cells is crucial for regenerative medicine and drug development.

Purpose of the Study:

  • To conduct the first assessment of agent-induced hormetic dose responses in iPSCs and their derivatives.
  • To investigate the mechanistic underpinnings of these hormetic responses.
  • To evaluate the therapeutic implications and compare findings with other stem cell types.

Main Methods:

  • Exposure of iPSCs and derived cells to a diverse range of chemical agents.
  • Agents included pharmaceuticals (metformin), plant extracts (curcumin), and endogenous compounds (melatonin).
  • Analysis of dose-response relationships to identify hormetic patterns.

Main Results:

  • Demonstrated agent-induced hormetic dose responses in iPSCs and derived cells.
  • Identified specific chemicals capable of inducing hormesis in these cell types.
  • Provided initial insights into the mechanistic basis of iPSC hormesis.

Conclusions:

  • Agent-induced hormesis is a relevant phenomenon in induced pluripotent stem cells.
  • These findings have implications for understanding stem cell behavior and therapeutic applications.
  • Further research is warranted to fully elucidate the mechanisms and exploit the therapeutic potential of iPSC hormesis.