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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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Weighing in on Adipogenesis.

Elizabeth R Nunn1, Abhijit B Shinde1, Elma Zaganjor1

  • 1Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, United States.

Frontiers in Physiology
|March 14, 2022
PubMed
Summary
This summary is machine-generated.

Obesity increases health risks, but adipogenesis (new fat cell creation) can prevent metabolic decline. Understanding adipogenesis is key to developing new therapies for obesity and related disorders.

Keywords:
adipogenesisadiposeepigeneticsmetabolismmitochondria

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Area of Science:

  • Biochemistry
  • Metabolic Health
  • Obesity Research

Background:

  • Obesity is a global health issue linked to metabolic syndrome, type II diabetes, insulin resistance, and cancer.
  • White adipose tissue (WAT) expansion occurs via adipogenesis (hyperplasia) and hypertrophy.
  • Adipogenesis is crucial for preventing metabolic decline in obesity, unlike hypertrophy.

Purpose of the Study:

  • To review recent studies on adipogenesis regulation.
  • To explore targeting adipogenesis as a therapeutic strategy for metabolic disorders.

Main Methods:

  • Literature review of recent studies on adipogenesis.
  • Analysis of the role of adipogenesis in metabolic health and disease.

Main Results:

  • Adipogenesis plays a protective role in obesity, preventing metabolic dysfunction.
  • Increased adipogenesis is observed in metabolically healthy obesity.
  • Dysfunctional adipose tissue expansion contributes to metabolic diseases.

Conclusions:

  • Understanding the mechanisms regulating adipogenesis is vital for developing new treatments.
  • Targeting adipogenesis offers a promising therapeutic avenue for metabolic disorders.