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SDC: An integrated database for sex differences in cancer.

Long-Fei Zhao1,2,3,4,5, Jin-Ge Zhang1,2,3,4,5, Feng-Yu Qi1,2,3,4,5

  • 1Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.

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Sex differences significantly impact cancer incidence and outcomes. The new Sex Differences in Cancer (SDC) database provides a comprehensive resource to explore these disparities in 27 cancer types.

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CancerDatabaseDifferencesSex

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Area of Science:

  • Oncology
  • Genomics
  • Bioinformatics

Background:

  • Sex-based disparities are observed in cancer incidence and mortality.
  • The influence of sex differences is underrepresented in cancer research and personalized medicine.
  • Molecular mechanisms driving sex differences in cancer remain largely unknown.

Purpose of the Study:

  • To develop the first integrated web-based database, Sex Differences in Cancer (SDC), for analyzing sex-based disparities in cancer.
  • To consolidate data from major resources like TCGA, GTEx, and CCLE for comprehensive analysis.
  • To facilitate the systematic investigation of sex differences across various cancer types and molecular data.

Main Methods:

  • Integrated data from TCGA, GTEx, UCSC Xena, CCLE, and GDSC.
  • Analyzed sex differences in 27 cancer types using 6 molecular data types.
  • Included data from over 10,000 donors and 977 cancer cell lines.
  • Developed five modules: Survival and phenotype, Molecular differences, Signatures and pathways, Therapy response, and Download.

Main Results:

  • The SDC database provides a unified platform for exploring sex differences in cancer.
  • It enables analysis of survival, phenotype, molecular alterations, and therapeutic responses.
  • Users can access and download visualized results and raw data for further research.

Conclusions:

  • SDC is the pioneering integrated database for web-based analysis of sex differences in cancer.
  • This resource is expected to enhance understanding of sex's role in cancer development and progression.
  • The database is freely accessible to the research community to advance cancer research.