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Three-dimensional light-field microendoscopy with a GRIN lens array.

Tara M Urner1,2, Andrew Inman1,2, Benjamin Lapid1,2

  • 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.

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|March 14, 2022
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This study introduces GRIN lens array microendoscopy (GLAM), a novel system for quantitative 3D imaging in surgery. GLAM enables precise volumetric tissue rendering, advancing minimally invasive procedures.

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Area of Science:

  • Medical Imaging
  • Optical Engineering
  • Surgical Technology

Background:

  • Current optical endoscopy systems provide 2D images, limiting 3D surgical visualization.
  • Existing 3D endoscopes offer stereoscopic vision but lack quantitative volumetric data.
  • High-precision surgery and medical robotics require advanced tools for tissue tomography.

Purpose of the Study:

  • To develop a single-shot, full-color, quantitative 3D microendoscopy system.
  • To enable computational synthesis of 3D volumes using light-field imaging.
  • To create a compact and clinically translatable endoscopic imaging solution.

Main Methods:

  • Utilized GRIN lens array microendoscopy (GLAM) with integrated fiber optics for illumination.
  • Captured light fields using a GRIN lens array to record spatial and angular information.
  • Employed computational methods to synthesize 3D volumes from captured light-field data.

Main Results:

  • Achieved a 3D resolution of approximately 100 µm over an imaging depth of 22 mm.
  • Demonstrated a field of view up to 1 cm².
  • Maintained a small form factor suitable for clinical applications.

Conclusions:

  • GLAM offers quantitative 3D microendoscopy, overcoming limitations of current endoscopic technologies.
  • The system's ability to render tissue volumes supports high-precision microsurgery and robotics.
  • GLAM is a promising, clinically translatable prototype for advanced surgical visualization.