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Published on: September 11, 2015
Bone Bricks: The Effect of Architecture and Material Composition on the Mechanical and Biological Performance of Bone
Evangelos Daskalakis1, Boyang Huang1, Cian Vyas1
1School of Mechanical, Aerospace and Civil Engineering, University of Manchester, ManchesterM13 9PL, U.K.
Abstract:
Large bone loss injuries require high-performance scaffolds with an architecture and material composition resembling native bone. However, most bone scaffold studies focus on three-dimensional (3D) structures with simple rectangular or circular geometries and uniform pores, not able to recapitulate the geometric characteristics of the native tissue. This paper addresses this limitation by proposing novel anatomically designed scaffolds (bone bricks) with nonuniform pore dimensions (pore size gradients) designed based on new lay-dawn pattern strategies. The gradient design allows one to tailor the properties of the bricks and together with the incorporation of ceramic materials allows one to obtain structures with high mechanical properties (higher than reported in the literature for the same material composition) and improved biological characteristics.
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