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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Updated: Sep 30, 2025

Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
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Randomized multi-angle illumination for improved linear array photoacoustic computed tomography in brain.

Rayyan Manwar1, Juliana Benavides Lara1, Ravi Prakash1

  • 1The Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, Illinois, USA.

Journal of Biophotonics
|March 14, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a multi-angle illumination technique for photoacoustic computed tomography, improving deep tissue imaging. The method enhances image quality and allows visualization of structures at greater depths.

Keywords:
brainlinear array transducermulti-angle illuminationphotoacoustic tomography

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Photoacoustic Tomography

Background:

  • Linear array transducer-based photoacoustic computed tomography (PACT) faces challenges in imaging deep biological structures due to limited optical energy.
  • Conventional PACT often uses fixed-angle illumination, restricting photon interaction time and diffusion.

Purpose of the Study:

  • To develop and evaluate a manually controlled multi-angle illumination technique for PACT.
  • To enhance the imaging of deep-seated structures in biological tissues.

Main Methods:

  • A compact probe was developed for manual adjustment of illumination angles during photoacoustic signal acquisition.
  • Multi-angle illumination was employed to increase photon interaction time and diffusion.
  • Image reconstruction utilized a maximum intensity extraction method.
  • Performance was evaluated using blood vessel phantoms and ex-vivo sheep brain samples.

Main Results:

  • Multi-angle illumination significantly improved overall image quality compared to fixed-angle illumination.
  • The technique enabled the imaging of targets at greater axial depths.
  • Complex blood vessel structures and sheep brain vasculature were successfully visualized.

Conclusions:

  • Manual multi-angle illumination is an effective strategy to overcome the limitations of deep tissue imaging in PACT.
  • This technique offers improved image quality and depth penetration for biomedical applications.