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Silicon-Vacancy Nanodiamonds as High Performance Near-Infrared Emitters for Live-Cell Dual-Color Imaging and
Weina Liu1,2,3, Md Noor A Alam1,2, Yan Liu4,5
1Max-Planck-Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Nano Letters
|March 15, 2022
Summary
Metal-catalyst-free synthesized nanodiamonds with silicon-vacancy (SiV) centers enable live-cell dual-color bioimaging and intracellular tracking. These nanodiamonds also function as nanosized thermometers for advanced diagnostic applications.
Area of Science:
- Materials Science
- Biotechnology
- Quantum Physics
Background:
- Nanodiamonds (NDs) with color centers are promising for bioimaging and quantum biosensing.
- Silicon-vacancy (SiV) centers in NDs offer unique optical properties like near-infrared emission and high photostability.
Purpose of the Study:
- To explore novel applications of metal-catalyst-free synthesized NDs with SiV centers.
- To demonstrate the utility of SiV-NDs for live-cell dual-color bioimaging, intracellular tracking, and thermometry.
Main Methods:
- High-pressure, high-temperature (HPHT) synthesis of NDs with SiV centers using a metal-catalyst-free method.
- Coating NDs with a polypeptide biopolymer to enhance cellular uptake.
- Utilizing the optical properties of SiV centers for imaging and thermometry.
Main Results:
- Successful synthesis of NDs with SiV centers via metal-catalyst-free HPHT growth.
- Demonstration of live-cell dual-color imaging and intracellular tracking using SiV-NDs.
- Investigation of intracellular thermometry capabilities and challenges related to SiV defects.
Conclusions:
- NDs with SiV nanoemitters offer new possibilities for live-cell bioimaging and diagnostics.
- SiV-NDs can serve as nanosized thermometers for intracellular temperature measurements.
- Potential for theranostic applications, utilizing nanodiamonds as drug carriers.
