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Two new bibenzyls from Pleione grandiflora (Rolfe) Rolfe and their antioxidant activity
Wei Li1, Jia-Rui Fu2, Li-Jun Zheng3
1College of Landscape Architecture, Fujian Agriculture and Forestry University, Fuzhou, P. R. China.
Natural Product Research
|March 15, 2022
Summary
Two new bibenzyl compounds were discovered in Pleione grandiflora pseudobulbs. These compounds, along with known ones, demonstrated significant antioxidant activity by scavenging free radicals.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Medicinal Chemistry
Background:
- Pleione grandiflora (Rolfe) Rolfe is a plant species known for its potential bioactive compounds.
- Bibenzyls are a class of natural products with diverse biological activities.
- Understanding the chemical constituents of medicinal plants is crucial for drug discovery.
Purpose of the Study:
- To isolate and characterize new bibenzyl compounds from Pleione grandiflora.
- To evaluate the antioxidant potential of isolated compounds using DPPH free radical scavenging assay.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation of isolated compounds via spectroscopic methods (e.g., NMR, MS).
- In vitro antioxidant activity assessment using the DPPH assay.
Main Results:
- Two novel bibenzyls, compounds 1 and 2, were successfully isolated and identified.
- Six known bibenzyls, including isoarundinin I, isoarundinin II, bulbocodin D, batatasin III, compound 7, and shancigusin F, were also identified.
- All isolated compounds exhibited potent DPPH free radical scavenging effects, with IC50 values ranging from 49.72 ± 0.35 μM to 65.41 ± 0.49 μM.
Conclusions:
- Pleione grandiflora pseudobulbs are a rich source of structurally diverse bibenzyls.
- The isolated bibenzyls possess significant antioxidant properties, suggesting potential therapeutic applications.
- Further research into these compounds may lead to the development of new antioxidant agents.
