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Insulin oedema.

D J Evans, K Pritchard-Jones, B Trotman-Dickenson

    Postgraduate Medical Journal
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Severe insulin-induced edema is a rare complication where patients experience significant fluid retention and weight gain. This condition can be managed with diuretics and albumin therapy.

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    Area of Science:

    • Endocrinology
    • Nephrology
    • Internal Medicine

    Background:

    • Uncontrolled diabetes mellitus requires prompt management, often involving insulin therapy.
    • Insulin therapy can have various side effects, necessitating careful patient monitoring.

    Observation:

    • A 35-year-old underweight woman with uncontrolled diabetes presented with significant fluid retention after initiating insulin therapy.
    • She experienced rapid weight gain (18.8 kg in 22 days), peripheral edema, and bilateral pleural effusions, alongside decreased plasma albumin levels.

    Findings:

    • The patient's condition improved markedly with diuretic and salt-poor albumin treatment, resulting in a 10.3 kg weight loss in 6 days.
    • Resolution of edema and fluid retention was achieved without recurrence.

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    Implications:

    • Severe insulin edema is an uncommon but significant complication of insulin therapy.
    • Potential mechanisms include insulin's effects on vascular permeability and renal tubular function.
    • Highlights the importance of recognizing and managing fluid retention in patients on insulin therapy.