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Availability of Fibrinogen/Albumin ratio in MS attack
Esen Çiçekli1, Saadet Sayan2, Dilcan Kotan2
1Department of Neurology, Akyazı State Hospital, Sakarya, Turkey.
Background/Aim:
Multiple sclerosis (MS) is a chronic central nervous system inflammatory disease. Fibrinogen/Albumin ratio (FAR) has been studied as an inflammatory marker in the past, and its significant relationship with inflammation has been shown. In our study, we examined serum levels of albumin, fibrinogen and FAR in patients presenting with MS attack. We investigated its usability in the diagnosis and management of MS attacks.
Materials And Methods:
This retrospective study included 40 patients admitted to hospital with MS attack and 40 control patients. All patients' demographics, medical history, the mean Expanded Disability Status Scale (EDSS), imaging findings and laboratory tests were extracted from medical records. Patients' fibrinogen, albumin levels were recorded in the blood tests performed before steroid administration, and FAR values were calculated. The patients' and controls' results were compared.
Results:
Fibrinogen and FAR values were significantly higher in the patient group (p<0.001 in both). There was no difference between the patient and control groups in terms of albumin (p = 0,16). No significant relationship was found between parameters such as EDSS, disease duration, smoking status and FAR value (p>0.05 in all).
Conclusion:
Serum fibrinogen and FAR levels in the patients presenting with an attack were significantly higher than the control group. FAR value did not vary with disease duration and EDSS score. Based on this information, FAR may be a useful indicator for MS attack regardless of EDSS and disease duration.
Insights
The Fibrinogen/Albumin Ratio (FAR) is elevated during multiple sclerosis (MS) attacks. This inflammatory marker may help diagnose MS attacks, irrespective of disease duration or severity.
Area of Science:
- Neurology
- Immunology
- Biochemistry
Background:
- Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
- The Fibrinogen/Albumin Ratio (FAR) is a recognized marker of inflammation.
- Previous studies indicate a link between FAR and inflammatory conditions.
Purpose of the Study:
- To investigate serum albumin, fibrinogen, and FAR levels in patients experiencing an MS attack.
- To evaluate the utility of FAR in diagnosing and managing MS attacks.
Main Methods:
- Retrospective study comparing 40 MS attack patients with 40 controls.
- Collected demographic, clinical, and laboratory data, including pre-treatment fibrinogen and albumin levels.
- Calculated FAR and compared values between groups.
Main Results:
- Significantly higher fibrinogen and FAR levels were observed in the MS attack group compared to controls (p<0.001).
- No significant difference in albumin levels was found between the groups (p=0.16).
- No correlation was found between FAR and Expanded Disability Status Scale (EDSS), disease duration, or smoking status.
Conclusions:
- Serum fibrinogen and FAR are elevated during MS attacks.
- FAR serves as a potential indicator for MS attacks, independent of disease duration and EDSS.
- FAR may be a valuable biomarker in the clinical management of MS exacerbations.
