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Updated: Sep 30, 2025
08:17
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
14.6K
Left ventricular hypertrophy is independently associated with all-cause mortality
Mohammad Reza Movahed1,2, Radhakrishnan Ramaraj1, Coraly Manrique1
1University of Arizona Sarver Heart Center Tucson, AZ 85724, USA.
American Journal of Cardiovascular Disease
|March 16, 2022
Summary
Left Ventricular Hypertrophy (LVH) significantly increases the risk of all-cause mortality. This large echocardiographic study confirms LVH is an independent predictor of long-term adverse outcomes.
Area of Science:
- Cardiology
- Echocardiography
- Clinical Outcomes
Background:
- Left Ventricular Hypertrophy (LVH) is a known risk factor for adverse health outcomes.
- The prognostic implications of LVH require further elucidation in large patient cohorts.
Purpose of the Study:
- To investigate the association between Left Ventricular Hypertrophy (LVH) and all-cause mortality.
- To utilize a substantial echocardiographic database for robust outcome analysis.
Main Methods:
- Retrospective analysis of 2,352 echocardiograms (ages 16-99) performed between 1983-1998.
- Mortality data were collected through national databases up to 2007.
- Uni- and multivariate analyses were employed to assess the relationship between LVH (wall thickness >11 mm) and total mortality.
Main Results:
- LVH demonstrated a significant association with all-cause mortality (35.5% vs. 23.5%, P<0.001, HR 1.79).
- Even after adjusting for age, gender, systolic function, and valvular disease, LVH remained an independent predictor of mortality (OR 1.39, P=0.005).
Conclusions:
- Left Ventricular Hypertrophy is independently associated with increased all-cause mortality.
- These findings underscore the detrimental impact of LVH on long-term patient survival.
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