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Left ventricular hypertrophy is independently associated with all-cause mortality

Mohammad Reza Movahed1,2, Radhakrishnan Ramaraj1, Coraly Manrique1

  • 1University of Arizona Sarver Heart Center Tucson, AZ 85724, USA.

American Journal of Cardiovascular Disease
|March 16, 2022
PubMed

Insights

Left Ventricular Hypertrophy (LVH) significantly increases the risk of all-cause mortality. This large echocardiographic study confirms LVH is an independent predictor of long-term adverse outcomes.

Area of Science:

  • Cardiology
  • Echocardiography
  • Clinical Outcomes

Background:

  • Left Ventricular Hypertrophy (LVH) is a known risk factor for adverse health outcomes.
  • The prognostic implications of LVH require further elucidation in large patient cohorts.

Purpose of the Study:

  • To investigate the association between Left Ventricular Hypertrophy (LVH) and all-cause mortality.
  • To utilize a substantial echocardiographic database for robust outcome analysis.

Main Methods:

  • Retrospective analysis of 2,352 echocardiograms (ages 16-99) performed between 1983-1998.
  • Mortality data were collected through national databases up to 2007.
  • Uni- and multivariate analyses were employed to assess the relationship between LVH (wall thickness >11 mm) and total mortality.

Main Results:

  • LVH demonstrated a significant association with all-cause mortality (35.5% vs. 23.5%, P<0.001, HR 1.79).
  • Even after adjusting for age, gender, systolic function, and valvular disease, LVH remained an independent predictor of mortality (OR 1.39, P=0.005).

Conclusions:

  • Left Ventricular Hypertrophy is independently associated with increased all-cause mortality.
  • These findings underscore the detrimental impact of LVH on long-term patient survival.
Abstract

Keywords:
LVHLeft ventricular hypertrophycardiovascular death: mortalityechocardiographyleft ventricular mass

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