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Biochemical, structural and physical changes in aging human skin, and their relationship
1Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, 21218, USA. smpark138@gmail.com.
Biogerontology
|March 16, 2022
Summary
Aging significantly alters skin properties, impacting its functions and health. This review explores the interconnected changes in biochemical, structural, and physical aspects of aging skin to understand underlying mechanisms and guide treatments.
Area of Science:
- Dermatology
- Gerontology
- Biomedical Engineering
Background:
- Skin aging involves complex biochemical, structural, and physical alterations.
- These changes can impair skin functions and lead to age-related diseases.
- Existing research often documents individual property changes but lacks focus on their interrelationships during aging.
Purpose of the Study:
- To provide a comprehensive overview of aging-induced changes in skin's biochemical, structural, and physical properties.
- To explore the relationships and potential mechanisms linking these properties during the aging process.
- To highlight the need for standardized methods and layer-specific analyses in aging skin research.
Main Methods:
- Review of existing literature on skin aging.
- Analysis of in vivo, ex vivo, and in vitro studies characterizing skin properties.
- Synthesis of findings on aging-related changes in biochemical, structural, and physical parameters.
Main Results:
- Aging induces diverse and sometimes contradictory changes in skin's biochemical, structural, and physical properties.
- The interconnections between these properties and their underlying mechanisms in aging are not fully elucidated.
- Current methods for characterizing aging skin lack standardization, hindering precise age-property relationship definitions.
Conclusions:
- Understanding the interplay between biochemical, structural, and physical changes is crucial for comprehending skin aging.
- Standardized methodologies and stratified analysis of skin layers are needed for accurate evaluation and treatment of aging skin.
- This review provides a framework for future research to improve therapeutic strategies for age-related skin conditions.
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