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TRPM8 agonist (cryosim-1) gel for scalp itch: a randomised, vehicle-controlled clinical trial

S Y Kang1, M G Choi2, E T Wei3

  • 1Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul, Korea.

Journal of the European Academy of Dermatology and Venereology : JEADV
|March 16, 2022
PubMed
Abstract

No abstract available in PubMed .

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...