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Updated: Sep 30, 2025

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Biofabricating hollow microneedle array with controllable microstructure for cell transplantation.

Ying-Hou Chen¹, Fang-Ying Wang^1,2, Yong-Shi Chan¹

¹Department of Biomedical Engineering, College of Engineering, College of Medicine, National Taiwan University, Taipei, Taiwan.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials

|March 16, 2022

Summary

Poly(methyl methacrylate) hollow microneedles (HMN) offer a painless method for cell delivery. These biocompatible microneedles successfully transplanted various human cells into porcine tissues, showing potential for cell transplantation therapies.

Keywords:

cell delivery cell transplantation hollow microneedle microneedle arrays

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Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Traditional drug delivery methods like direct injection face limitations in delivering large molecules across the skin barrier.
Microneedle technology offers a minimally invasive approach to create microchannels for enhanced transdermal delivery.
Hollow microneedles (HMN) present a novel platform for localized delivery of therapeutic agents, including cells.

Purpose of the Study:

To fabricate and evaluate poly(methyl methacrylate) (PMMA) hollow microneedle (HMN) arrays for cell transplantation.
To assess the biocompatibility and efficacy of HMN arrays in delivering various human cell types to acellular tissues.
To investigate the potential of HMN-mediated cell delivery for applications in regenerative medicine.

Main Methods:

Fabrication of poly(methyl methacrylate) (PMMA) based hollow microneedle (HMN) arrays.
Delivery of human epidermal melanocytes, follicle dermal papilla cells, corneal keratocytes, and corneal epithelial cells using HMN arrays.
Assessment of cell viability, proliferation, and tissue integration in acellular porcine skin and corneal tissues.

Main Results:

The fabricated HMN arrays demonstrated good biocompatibility.
Successful delivery and integration of human epidermal melanocytes and follicle dermal papilla cells into acellular porcine skin tissue.
Successful delivery and integration of human corneal keratocytes and corneal epithelial cells into acellular porcine corneal tissue.
Delivered cells exhibited proliferation and penetration into the target tissues.

Conclusions:

Poly(methyl methacrylate) hollow microneedle arrays are a viable and biocompatible platform for minimally invasive cell delivery.
This technology shows significant potential for applications in cell transplantation and regenerative medicine, including skin and corneal tissue repair.
Further research into HMN-mediated cell delivery could lead to advanced therapeutic strategies for various medical conditions.