Related Experiment Video
Updated: Sep 30, 2025
Development of a Uterosacral Ligament Suspension Rat Model
Published on: August 17, 2022
Urinary basement membrane graft-augmented sacrospinous ligament suspension: a description of technique and short-term
Douglas Luchristt1, Alison C Weidner2, Nazema Y Siddiqui2
1Division of Urogynecology, Department of Obstetrics & Gynecology, Duke University, 5324 McFarland Drive, Suite 310, Durham, NC, 27707, USA. Douglas.H.Luchristt@gmail.com.
Introduction And Hypothesis:
Since the discontinuation of manufacture and distribution of surgical mesh for transvaginal prolapse repair, the use of biologic grafts for transvaginal apical suspension has gained renewed attention. However, there is no FDA-approved device and minimal published data describing such an approach. The objective of this video is to describe a technique and to present limited short-term outcomes utilizing a porcine urinary basement membrane (UBM) graft to perform an augmented bilateral sacrospinous ligament suspension (SSLS).
Methods:
We present a step-by-step overview of our technique to perform an augmented SSLS with off-label utilization of a 7- × 10-cm porcine UBM graft. We demonstrate graft shaping and application during transvaginal repair along with data describing perioperative outcomes associated with a series of 25 cases performed at our institution using the technique described.
Results:
No perioperative complications related to the graft were observed in our cohort. The most common postoperative concern was buttock pain, which spontaneously resolved within 6 months. Two individuals (8%) developed recurrent prolapse within 1 year of surgery.
Conclusions:
The UBM-augmented apical suspension allows for reinforced transvaginal prolapse repair without the use of permanent mesh material. We have observed good clinical success in our application of this technique, but dedicated research assessing long-term outcomes compared with a native tissue repair is needed.
