Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

5.8K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
5.8K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

1.1K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
1.1K
Sperm Transport01:15

Sperm Transport

1.6K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
1.6K
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

4.2K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
4.2K
Accessory Glands of the Male Reproductive System01:16

Accessory Glands of the Male Reproductive System

2.2K
The accessory ducts involved in sperm maturation and transportation include the epididymides, vasa deferentia, ejaculatory ducts, and urethra. These ducts play a critical role in the maturation, storage, and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...
2.2K
What is Gene Expression?01:42

What is Gene Expression?

173.0K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
173.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Air pollution could drive global dissemination of antibiotic resistance genes.

The ISME journal·2020
Same author

Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing.

Science advances·2020
Same author

Earthworm gut: An overlooked niche for anaerobic ammonium oxidation in agricultural soil.

The Science of the total environment·2020
Same author

MicroRNA-199a Inhibits Cell Proliferation, Migration, and Invasion and Activates AKT/mTOR Signaling Pathway by Targeting B7-H3 in Cervical Cancer.

Technology in cancer research & treatment·2020
Same author

Hypoglycemic and Hypolipidemic Mechanism of Tea Polysaccharides on Type 2 Diabetic Rats via Gut Microbiota and Metabolism Alteration.

Journal of agricultural and food chemistry·2020
Same author

The prevalence of rheumatoid arthritis in middle-aged and elderly people living in Naqu City, Tibet, Autonomous Region of China.

Journal of orthopaedic surgery and research·2020

Related Experiment Video

Updated: Sep 30, 2025

Analysis of Epididymal Protein Synthesis and Secretion
10:23

Analysis of Epididymal Protein Synthesis and Secretion

Published on: August 25, 2018

9.5K

BGIG10116_34868: A Newly Discovered Gene Regulating Ejaculation Function.

Jingjing Gao1, Rui Gao1, Hu Li1

  • 1Department of Urology and Andrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Frontiers in Physiology
|March 17, 2022
PubMed
Summary

Researchers identified key genes associated with premature ejaculation (PE) using whole-transcriptome sequencing in rat models. This study aims to uncover genetic factors contributing to PE and inform targeted therapies for this common ejaculation dysfunction.

Keywords:
ejaculation functiongeneslifelong premature ejaculation (lifelong PE)ratserotonin transporter

More Related Videos

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
06:38

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

15.8K
Phosphopeptide Analysis of Rodent Epididymal Spermatozoa
09:30

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Published on: December 30, 2014

13.1K

Related Experiment Videos

Last Updated: Sep 30, 2025

Analysis of Epididymal Protein Synthesis and Secretion
10:23

Analysis of Epididymal Protein Synthesis and Secretion

Published on: August 25, 2018

9.5K
Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
06:38

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

15.8K
Phosphopeptide Analysis of Rodent Epididymal Spermatozoa
09:30

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Published on: December 30, 2014

13.1K

Area of Science:

  • Neuroscience
  • Genetics
  • Urology

Background:

  • Ejaculation is a complex neurophysiological process.
  • Ejaculation dysfunction, particularly lifelong premature ejaculation (LPE), affects many individuals.
  • The genetic underpinnings of LPE remain largely unclarified, hindering effective treatment.

Purpose of the Study:

  • To identify genetic loci contributing to the etiology of premature ejaculation (PE).
  • To provide a theoretical basis for targeted therapies for PE.
  • To screen for differential genes in rat models exhibiting varied ejaculation times.

Main Methods:

  • Established three groups of ejaculation rats: 'rapid', 'normal', and 'delayed'.
  • Utilized whole-transcriptome sequencing on rat brain tissue.
  • Screened for differentially expressed genes among the three experimental groups.

Main Results:

  • Identified specific genes that show differential expression across rat groups with varying ejaculation times.
  • The 'rapid' ejaculation rat group serves as a potential model for studying human PE.
  • This screening provides a foundation for understanding the genetic basis of PE.

Conclusions:

  • Gene polymorphism may play a significant role in the etiology of lifelong premature ejaculation (LPE).
  • Whole-transcriptome sequencing is a viable method for identifying genetic factors in PE.
  • Further research into these identified genetic loci could lead to novel therapeutic strategies for PE.