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Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
Published on: February 8, 2018
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In-vivo functional and structural retinal imaging using multiwavelength photoacoustic remote sensing microscopy
Zohreh Hosseinaee1, Nicholas Pellegrino1, Nima Abbasi1
1PhotoMedicine Labs, Department of System Design Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON, N2L 3G1, Canada.
Scientific Reports
|March 17, 2022
Summary
Photoacoustic remote sensing (PARS) offers novel non-contact in-vivo retinal imaging for assessing microanatomy and oxygen saturation. This breakthrough advances understanding and monitoring of retinal diseases.
Area of Science:
- Ophthalmology
- Biomedical Optics
- Medical Imaging
Background:
- Retinal diseases and systemic disorders often manifest in the retina.
- Advanced retinal imaging provides detailed in-vivo information on retinal structure, function, and molecular composition.
- Photoacoustic remote sensing (PARS) is an emerging all-optical imaging technique suitable for medical applications.
Purpose of the Study:
- To apply PARS for non-contact in-vivo imaging of the retina.
- To estimate oxygen saturation in retinal vasculature using PARS.
- To demonstrate the capabilities of PARS combined with optical coherence tomography for retinal microanatomy and microvasculature imaging.
Main Methods:
- Utilized photoacoustic remote sensing (PARS) for non-contact in-vivo retinal imaging.
- Integrated optical coherence tomography (OCT) for navigation and validation.
- Applied the PARS system to image retinal microanatomy and microvasculature in vivo.
Main Results:
- Successfully performed non-contact in-vivo imaging of the retina using PARS.
- Demonstrated the capability to estimate oxygen saturation in retinal vasculature.
- Showcased imaging of retinal microanatomy and microvasculature.
Conclusions:
- PARS is a pioneering non-contact technique for in-vivo retinal imaging.
- The developed system can aid in understanding the ocular environment.
- This technology holds potential for monitoring ophthalmic diseases.
