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A Novel Solid-State PVC-Membrane Potentiometric Dopamine-Selective Sensor Based on Molecular Imprinted Polymer.
Nurşen Dere1, Zuhal Yolcu, Murat Yolcu
1Giresun University, Center Research Laboratory Application and Research Center, Giresun. nursen.dere@giresun.edu.tr.
Acta Chimica Slovenica
|March 17, 2022
Summary
A new polyvinylchloride (PVC) microsensor selectively detects dopamine using a molecularly imprinted polymer. This accurate and rapid sensor shows promise for analyzing dopamine in pharmaceutical formulations.
Area of Science:
- Electroanalytical Chemistry
- Polymer Science
- Materials Science
Background:
- Dopamine is a crucial neurotransmitter with implications in neurological disorders.
- Accurate and selective detection of dopamine is essential for diagnostics and drug development.
- Existing detection methods may lack sensitivity, selectivity, or require complex procedures.
Purpose of the Study:
- To develop a novel solid-state polyvinylchloride (PVC) membrane potentiometric microsensor for selective dopamine detection.
- To optimize the membrane composition for enhanced performance and stability.
- To evaluate the microsensor's applicability in real-world pharmaceutical analysis.
Main Methods:
- Construction of a potentiometric microsensor using a dopamine-imprinted polymer (MIP) as the ionophore in a PVC membrane.
- Optimization of membrane composition including MIP, bis(2-ethylhexyl) sebacate (DOS), PVC, and potassiumtetrakis(4-chlorophenyl) borate (KTpClPB).
- Characterization of the microsensor's performance, including detection limit, response range, response time, stability, and operational conditions (pH, temperature).
Main Results:
- The optimized microsensor demonstrated a low detection limit of 3.71×10-7 mol.L-1.
- A stable, super-Nernstian response for dopamine was observed over a wide concentration range (10-6-10-1 mol.L-1) with a fast response time (<15 s).
- The microsensor showed excellent selectivity and reproducibility in determining dopamine in pharmaceutical formulations, with high recovery rates (104.3-104.8%).
Conclusions:
- The developed dopamine-imprinted polymer-based PVC microsensor offers a rapid, accurate, and selective method for dopamine determination.
- The microsensor's robust performance across various conditions and successful application in pharmaceutical analysis highlight its practical utility.
- This novel sensor provides a valuable tool for electrochemical analysis of dopamine in complex matrices.
