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QuatCy-I2 and MHI-I2 in Photodynamic Therapy
Sopida Thavornpradit1, Syed Muhammad Usama1, G Kate Park2
1Department of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842, United States.
ACS Medicinal Chemistry Letters
|March 18, 2022
Abstract:
MHI-I2 (1) and QuatCy-I2 (2) were compared in terms of properties important for early-stage photodynamic therapy preclinical candidates. Thus, experiments were performed to monitor dark cytotoxicities, light/dark cytotoxicity ratios, selectivity of localization in tumors over other organs, and clearance from the plasma.
