A Virtual Collection Focused on Antifungal Drug Discovery

Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's Disease.

ACS chemical neuroscience·2026

Optimization of Pyrazole-Based Activators of Kv3.1.

ACS medicinal chemistry letters·2026

Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.

ACS chemical neuroscience·2026

Rifamycin Structural Modifications Attenuate PXR Binding and CYP3A4 Induction.

Journal of medicinal chemistry·2026

Discovery of VU6066098: A Selective and CNS-Penetrant mGlu2 NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in Rodents.

ACS chemical neuroscience·2026

Discovery of VU6053371/BI03738809: A First-in-Class Selective and CNS-Penetrant mGlu3 Positive Allosteric Modulator (PAM) with Efficacy in a Preclinical Cognition Model.

ACS chemical neuroscience·2026

Novel Compounds with Aryl Linkers as Glucagon Receptor Agonists for Treating Type 2 Diabetes Mellitus and Obesity.

ACS medicinal chemistry letters·2026

The Great Potential of the Cluster of Differentiation 38 (CD38) Inhibitors in the Treatment of Cancer and Age-Related Metabolic dysfunction.

ACS medicinal chemistry letters·2026

Discovery of CTX-439: A Potent and Selective CDK12 Inhibitor as a Prospective Anti-Cancer Drug.

ACS medicinal chemistry letters·2026

Identification of Clofibric Acid as a Synoviolin (SYVN1) Ligand for Proteolysis-Targeting Chimera (PROTAC) Development.

ACS medicinal chemistry letters·2026

Probe and Assay Dependent Pharmacology of Dantrolene Analogues at the GPR35.

ACS medicinal chemistry letters·2026

Integrated network pharmacology and in vitro/in silico evaluation of the bioactive potential of Gundelia komagenensis fırat extracts.

Cytotechnology·2026

Evaluation of Novel Isatin-Schiff Base Derivatives: Monoamine Oxidase Inhibition and Antimicrobial Assessment.

ChemMedChem·2026

New sesquiterpenes and flavonoids from the fruits of Hypericum ascyron L. with nitric oxide inhibitory activities.

Fitoterapia·2026

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Allopurinol in Hyperuricemia Treatment.

Canadian journal of physiology and pharmacology·2026

Synthesis of polyhydroquinoline derivatives as potent antidiabetic and antioxidant agents: in vitro biological activities and computational studies.

Future medicinal chemistry·2026

An integrated approach: green extraction technique optimization, mechanistic study, and bioactivity profiling of four flavonoids from Epimedium sagittatum.

RSC advances·2026

Related Experiment Videos

A Virtual Collection Focused on Antifungal Drug Discovery

Related Concept Videos

Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's Disease.

Optimization of Pyrazole-Based Activators of Kv3.1.

Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.

Rifamycin Structural Modifications Attenuate PXR Binding and CYP3A4 Induction.

Discovery of VU6066098: A Selective and CNS-Penetrant mGlu2 NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in Rodents.

Discovery of VU6053371/BI03738809: A First-in-Class Selective and CNS-Penetrant mGlu3 Positive Allosteric Modulator (PAM) with Efficacy in a Preclinical Cognition Model.

Novel Compounds with Aryl Linkers as Glucagon Receptor Agonists for Treating Type 2 Diabetes Mellitus and Obesity.

The Great Potential of the Cluster of Differentiation 38 (CD38) Inhibitors in the Treatment of Cancer and Age-Related Metabolic dysfunction.

Discovery of CTX-439: A Potent and Selective CDK12 Inhibitor as a Prospective Anti-Cancer Drug.

Identification of Clofibric Acid as a Synoviolin (SYVN1) Ligand for Proteolysis-Targeting Chimera (PROTAC) Development.

Probe and Assay Dependent Pharmacology of Dantrolene Analogues at the GPR35.

Integrated network pharmacology and in vitro/in silico evaluation of the bioactive potential of Gundelia komagenensis fırat extracts.

Evaluation of Novel Isatin-Schiff Base Derivatives: Monoamine Oxidase Inhibition and Antimicrobial Assessment.

New sesquiterpenes and flavonoids from the fruits of Hypericum ascyron L. with nitric oxide inhibitory activities.

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Allopurinol in Hyperuricemia Treatment.

Synthesis of polyhydroquinoline derivatives as potent antidiabetic and antioxidant agents: in vitro biological activities and computational studies.

An integrated approach: green extraction technique optimization, mechanistic study, and bioactivity profiling of four flavonoids from Epimedium sagittatum.

Related Experiment Videos

A Virtual Collection Focused on Antifungal Drug Discovery

Related Concept Videos

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