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Differential Diagnosis of Nonabsorbable Inflammatory and Malignant Subsolid Nodules with a Solid Component ≤5 mm
Xiao-Qun He1, Xian Li2, Yan Wu3
1Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Journal of Inflammation Research
|March 18, 2022
Summary
Pulmonary subsolid nodules (SSNs) with small solid components show distinct clinical and CT features. Differentiating inflammatory from malignant SSNs aids in accurate diagnosis and patient management.
Area of Science:
- Pulmonary Medicine
- Radiology
- Oncology
Background:
- Subsolid nodules (SSNs) with small solid components (≤5 mm) present a diagnostic challenge.
- Distinguishing between inflammatory and malignant causes is crucial for appropriate clinical management.
Purpose of the Study:
- To investigate the differential clinical and computed tomography (CT) characteristics of pulmonary nonabsorbable inflammatory and malignant SSNs with a solid component ≤5 mm.
- To identify key factors that differentiate these two types of SSNs.
Main Methods:
- Retrospective analysis of 576 patients with SSNs (solid component ≤5 mm) who underwent surgical resection.
- Clinical and CT data were analyzed, and logistic regression was used to identify differentiating factors.
- An internal validation cohort of 146 patients was used to test the prediction model.
Main Results:
- Significant differences in 11 clinical and CT features were observed between inflammatory and malignant SSNs (P < 0.05).
- Key differentiating factors included respiratory symptoms, lobe distribution, nodule shape, CT value of GGO, intra-nodular vessels, and septal thickening.
- The model achieved an AUC of 0.843 in the training set and 0.830 in the validation set.
Conclusions:
- Nonabsorbable inflammatory and malignant SSNs with a solid component ≤5 mm exhibit distinct clinical and imaging characteristics.
- These findings can improve the accuracy of differentiating benign from malignant SSNs on CT scans.
