Related Experiment Videos
Sustained-release terbutaline in nocturnal asthma.
Allergy
|May 1, 1986
Summary
A single evening dose of sustained-release terbutaline improved morning lung function and reduced overnight decline in patients with nocturnal asthma. This treatment offers a potential benefit for managing nighttime asthma symptoms.
Area of Science:
- Pulmonology
- Pharmacology
Background:
- Nocturnal asthma significantly impacts patient quality of life.
- Effective management of nighttime asthma symptoms remains a clinical challenge.
Purpose of the Study:
- To evaluate the efficacy of sustained-release terbutaline in managing nocturnal asthma.
- To assess the impact of a single evening dose on lung function and symptoms.
Main Methods:
- Double-blind, randomized, cross-over study design.
- 15 adult patients with nocturnal asthma received SR terbutaline 7.5 mg or placebo nightly for one week.
- Evaluated evening and morning peak expiratory flow (PEF) and overnight PEF fall.
Main Results:
- Significant improvement in morning PEF (P < 0.05) with active treatment.
- Significant reduction in overnight fall of PEF (P < 0.01) on active treatment.
- Symptom improvement observed with both placebo and active medication.
Conclusions:
- A single evening dose of sustained-release terbutaline can be beneficial for patients with nocturnal asthma.
- SR-terbutaline demonstrates efficacy in improving key lung function parameters overnight.