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Sesquiterpene lactones from Artemisia mongolica
Ziwei Zhu1, Ablajan Turak2, Haji Akber Aisa2
1The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; University of the Chinese Academy of Sciences, Beijing, 100039, China.
Researchers isolated novel sesquiterpene lactones from Artemisia mongolica, determining their structures and configurations. Some compounds exhibited anti-inflammatory and antitumor activities, highlighting potential therapeutic applications.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Artemisia mongolica is a plant species known for its diverse chemical constituents.
- Sesquiterpene lactones are a class of natural products with a wide range of biological activities.
Purpose of the Study:
- To isolate and characterize novel and known sesquiterpene lactones from Artemisia mongolica.
- To elucidate the structures and absolute configurations of these compounds.
- To evaluate the biological activities of the isolated compounds.
Main Methods:
- Isolation and purification of compounds using chromatographic techniques.
- Structure elucidation using Nuclear Magnetic Resonance (NMR) spectroscopy, High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS), and Electronic Circular Dichroism (ECD).
- Determination of absolute configurations via single-crystal X-ray crystallography.
Main Results:
- Twelve new and seven known sesquiterpene lactones were isolated from Artemisia mongolica.
- The structures and absolute configurations of several compounds were confirmed.
- The X-ray crystal structure of artabsinolide E was reported for the first time.
- Beibersteneolide-B demonstrated moderate anti-inflammatory and marked antitumor activity.
- Artemyriantholide E exhibited moderate antitumor activity.
Conclusions:
- The study successfully identified and characterized multiple sesquiterpene lactones from Artemisia mongolica.
- The findings contribute to the understanding of the phytochemical diversity of this plant.
- The identified biological activities suggest potential for developing new therapeutic agents.
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