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Related Concept Videos

Amplifying Signals via Enzymatic Cascade01:22

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When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
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A DNA-Based Plasmonic Nanodevice for Cascade Signal Amplification.

Fengsong Liu1,2, Na Li1,2, Yingxu Shang1

  • 1CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190, China.

Angewandte Chemie (International Ed. in English)
|March 18, 2022
PubMed
Summary

This study introduces a DNA circuit-powered nanodevice that amplifies weak biological signals. The system uses gold nanorods on DNA origami to detect various molecules and report changes through plasmonic signals.

Keywords:
DNA OrigamiNanodevicesPlasmonic NanostructureSelf-AssemblySignal Amplification

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Area of Science:

  • Nanotechnology
  • Synthetic Biology
  • Biophysics

Background:

  • Developing sensitive biosensing platforms is crucial for early disease detection and molecular analysis.
  • Existing methods often face limitations in signal amplification and specificity.
  • Synthetic nanomachines offer novel strategies for complex biological signal processing.

Purpose of the Study:

  • To develop a DNA circuit-aided plasmonic nanodevice for amplifying faint chemical and biological signals.
  • To enable detection of diverse analytes including nucleic acids, small molecules, and tumor cell receptors.
  • To create a versatile platform for constructing synthetic nanomachines with customized bottom-up assembly.

Main Methods:

  • Co-assembly of two gold nanorods (GNRs) onto a DNA origami template with a DNA lock.
  • Utilizing DNA logic circuits as recognition and amplification elements for specific messengers.
  • Employing DNA keys to drive conformational changes in the plasmonic nanodevices upon signal detection.
  • Monitoring signal transduction via changes in plasmonic circular dichroism (CD) spectra.

Main Results:

  • Demonstrated a DNA nanodevice capable of DNA-regulated, cascade amplification of weak signals.
  • Showcased the system's ability to respond to various input signals: nucleic acids, adenosines, chiral tyrosinamides, and tumor cell receptors.
  • Observed robust signal reporting through distinct plasmonic circular dichroism spectral changes.
  • Validated the dynamic structural motion of nanodevices upon activation.

Conclusions:

  • The developed DNA nanodevice-based plasmonic system offers a novel approach for sensitive biological signaling.
  • This platform enriches strategies for constructing synthetic nanomachines with bottom-up assembly.
  • The system provides a customizable design for enhanced detection of faint chemical and biological signals.