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Multi-parameter Measurement of the Permeability Transition Pore Opening in Isolated Mouse Heart Mitochondria
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Probing the flux of mitochondrial potassium using an azacrown-diketopyrrolopyrrole based highly sensitive probe
G Dinesh Kumar1, Marzena Banasiewicz2, Antoni Wrzosek3
1Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland. dtgryko@icho.edu.pl.
Chemical Communications (Cambridge, England)
|March 18, 2022
Abstract:
The diketopyrrolopyrrole bearing an aza-18-crown-6 as a binding unit as well as a PPh3+ group is highly sensitive towards K+ and localizes selectively in mitochondria of cardiac H9C2 cells. Fast efflux/influx of mitochondrial K+ can be observed upon stimulation with nigericin.
