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Bioactive Peptides: From Basic Research to Clinical Trials and Commercialization.

Pauline Duffuler1, Khushwant S Bhullar1,2, Stepheny C de Campos Zani3

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Food-derived bioactive peptides show promise for managing chronic diseases. However, challenges in understanding their mechanisms, pharmacokinetics, and production hinder widespread clinical use and commercialization.

Keywords:
bioactive peptideschronic diseasesclinical trialscommercializationprotein hydrolysate

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Area of Science:

  • Nutritional Science
  • Biochemistry
  • Public Health

Background:

  • Chronic diseases, including metabolic disorders, represent a significant global health challenge.
  • Diet-based strategies using bioactive peptides and protein hydrolysates from food are gaining research interest for disease prevention and management.
  • Preclinical studies demonstrate the potential of these compounds as antihypertensive, anti-inflammatory, antidiabetic, and antioxidant agents.

Purpose of the Study:

  • To review the current clinical evidence on food-derived bioactive peptides and protein hydrolysates for chronic disease management.
  • To identify challenges hindering the clinical translation and commercialization of these bioactive compounds.

Main Methods:

  • Literature review of in vitro and in vivo studies.
  • Analysis of clinical trial data and commercialization barriers.

Main Results:

  • Numerous studies support the efficacy and safety of food-derived bioactive peptides and protein hydrolysates.
  • Limited understanding of mechanisms of action and pharmacokinetics restricts clinical application.
  • Barriers to commercialization include lack of efficacy data, safety concerns, bitter taste, and cost-effective production methods.

Conclusions:

  • Food-derived bioactive peptides and protein hydrolysates show therapeutic potential for chronic diseases.
  • Further research is needed to elucidate mechanisms, improve pharmacokinetics, and overcome commercialization hurdles.
  • Addressing challenges in efficacy, safety, taste, and production is crucial for clinical translation.