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Updated: Sep 29, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Phosphorescent biaryl platinum(IV) complexes obtained through double metalation of dibenzoiodolium ions
Juan-Carlos López-López1, Delia Bautista2, Pablo González-Herrero1
1Departamento de Química Inorgánica, Facultad de Química, Universidad de Murcia, Campus de Espinardo, 19, 30100 Murcia, Spain. pgh@um.es.
Abstract:
The first series of neutral, tris-chelate, phosphorecent Pt(IV) complexes is reported, which combine two cyclometalated 2-arylpyridine ligands and a dimetalated biaryl. The introduction of biaryl ligands is achieved under mild conditions through the oxidative addition of dibenzoiodolium ions to Pt(II) precursors to give Pt(IV) intermediates with a singly metalated 2-(2-iodoaryl)aryl ligand, followed by the reductive metalation of the C-I bond. The modulation of emission characteristics via derivatization of both types of ligands is demonstrated.
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