Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-dimensional melt growth of large-scale, single-crystalline hybrid organic-inorganic perovskite films.

Nature communications·2026
Same author

Ionic Landscape Engineering via Perovskite Quantum Dots for Reliable and Energy-Efficient Perovskite Memristors.

ACS nano·2026
Same author

DKK1 Suppresses Hippo Signaling via PIP<sub>3</sub>-OGT-LRP6 <i>O</i>-GlcNAcylation in Hepatocellular Carcinoma.

Cancer communications (London, England)·2026
Same author

From Static to Dynamic Security: Multidimensional and Reconfigurable Physical Unclonable Functions.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026
Same author

Defining an operational selectivity window for rare-earth flotation using a Box-Behnken design.

Scientific reports·2026
Same author

Publisher Correction: Dynamic realization of emergent high-dimensional optical vortices.

Nature communications·2026

Related Experiment Video

Updated: Sep 29, 2025

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

9.6K

Recyclable Periodic Nanostructure Formed by Sublimable Liquid Crystals for Robust Cell Alignment.

Min Jeong Shin1, San Hae Im2, Wantae Kim1

  • 1Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 18, 2022
PubMed
Summary

Researchers developed a recyclable nanogroove scaffold from liquid crystal material. This scaffold guides cell growth, influencing cell behavior and enabling the creation of organized cell sheets for bioengineering applications.

More Related Videos

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites
12:21

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

Published on: February 6, 2016

12.9K
High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
06:24

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal

Published on: October 31, 2019

6.5K

Related Experiment Videos

Last Updated: Sep 29, 2025

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

9.6K
Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites
12:21

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

Published on: February 6, 2016

12.9K
High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
06:24

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal

Published on: October 31, 2019

6.5K

Area of Science:

  • Biomaterials Science
  • Soft Matter Physics
  • Cell Biology

Background:

  • Developing advanced scaffolds is crucial for controlling cell behavior and tissue regeneration.
  • Existing methods often lack recyclability or precise nanotopographical control.

Purpose of the Study:

  • To create a facile and recyclable cell-alignment scaffold using liquid crystal (LC) based nanogrooves.
  • To investigate the impact of nanogroove topography on cell morphology and gene expression.
  • To demonstrate the potential for creating organized, transferable cell sheets.

Main Methods:

  • Fabrication of periodic nanogrooves via sublimation and recondensation of liquid crystal structures.
  • Surface treatment with osmium tetroxide (OsO4) to prepare the scaffold for cell culture.
  • Culturing various cell types on the nanogroove scaffold and standard substrates.
  • Analysis of cell morphology and gene expression using microscopy and quantitative polymerase chain reaction (qPCR).

Main Results:

  • Successfully fabricated recyclable nanogroove scaffolds with dimensions in the hundreds of nanometers.
  • Demonstrated efficient and non-cytotoxic directed cell growth on the nanogroove scaffold.
  • Observed distinct cell morphologies and gene expression patterns influenced by nanotopography compared to control substrates.
  • Formed transferable cell sheets composed of oriented cells.

Conclusions:

  • The developed liquid crystal-based nanogroove scaffold offers a versatile and reusable platform for controlling cell alignment and behavior.
  • This technology has broad applicability in bioengineering, impacting fundamental understanding of cell function and regenerative medicine.
  • The ability to create and transfer organized cell sheets opens new avenues for tissue engineering and soft material applications.