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Related Concept Videos

Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

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Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
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Transcytosis of IgG01:15

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Nephrotic Syndrome I : Introduction01:24

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Updated: Sep 29, 2025

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
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[Update on immunoglobulin A vasculitis].

Thomas Neumann1,2

  • 1Klinik für Rheumatologie, Kantonsspital St. Gallen, Rorschacher Str. 95, 9007, St. Gallen, Schweiz. thomas.neumann@kssg.ch.

Zeitschrift Fur Rheumatologie
|March 18, 2022
PubMed
Summary
This summary is machine-generated.

Immunoglobulin A vasculitis (IgAV) is a common childhood vasculitis, typically self-limiting. In adults, IgAV is rarer but can present with severe renal or gastrointestinal issues, impacting long-term prognosis.

Keywords:
Henoch-Schoenlein purpuraManifestationsPrognosisSmall vessel vasculitisTreatment

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Area of Science:

  • Rheumatology
  • Pediatric Rheumatology
  • Nephrology

Background:

  • Immunoglobulin A vasculitis (IgAV) is a systemic small vessel vasculitis characterized by IgA immune complex deposition.
  • It commonly affects children, usually with a self-limiting course, but can be more severe in adults, particularly with renal and gastrointestinal involvement.

Purpose of the Study:

  • To provide a comprehensive overview of Immunoglobulin A vasculitis (IgAV).
  • To discuss the pathophysiology, clinical manifestations, and current therapeutic strategies for IgAV.

Main Methods:

  • Review of existing literature on IgAV.
  • Analysis of clinical presentations and outcomes across different age groups.
  • Evaluation of current treatment guidelines and evidence.

Main Results:

  • IgAV presents with purpura, arthralgia/arthritis, enteritis, and glomerulonephritis.
  • Impaired IgA1 glycosylation is a key pathophysiological factor.
  • Adult cases are less frequent but associated with higher risks of severe organ damage.

Conclusions:

  • The prognosis of IgAV is primarily dictated by the presence and severity of renal manifestations.
  • Symptomatic treatment is standard for benign cases; immunosuppressants are used cautiously based on organ involvement severity.
  • Further research is needed to strengthen evidence for therapeutic strategies.