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Updated: Sep 29, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Cu-catalyzed, Mn-mediated propargylation and allenylation of aldehydes with propargyl bromides
Rongli Zhang1, Yanping Xia2, Yuchen Yan3
1Xuzhou Medical University, Tongshan Road 209, Xuzhou, 221004, China. 1543046703@qq.com.
Abstract:
A simple, practical, and high chemo-selective method for the synthesis of propargyl alcohol and allenyl alcohols via Cu-catalyzed, Mn-mediated propargylation and allenylation of aldehydes with propargyl bromides has been established. When 3-bromo-1-propyne was conducted under the standard condition, the aldehydes were transformed to the corresponding propargylation products completely, while when 1-bromo-2-pentyne was used, allenic alcohol was the only product. Variety of homopropargyl alcohols and allenyl alcohols were obtained in high yields and the reaction is compatible with broad substrate scopes. In addition, the large-scale reaction could also be proceeded smoothly indicating the potential synthetic applications of this transformation.
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