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Advancing automation in high-throughput screening: Modular unguarded systems enable adaptable drug discovery
Catherine S Hansel1, Darren L Plant1, Geoffrey A Holdgate1
1High-Throughput Screening, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Alderley Park, UK.
Drug Discovery Today
|March 19, 2022
Summary
AstraZeneca
Area of Science:
- Drug discovery automation
- High throughput screening technologies
Background:
- Ageing infrastructure in screening departments poses challenges.
- Increasingly demanding screening cascades require advanced solutions.
Purpose of the Study:
- To develop advanced automation systems for drug discovery.
- To enhance flexibility and productivity in high throughput screening.
Main Methods:
- Collaborative development with vendors like HighRes Biosolutions.
- Implementation of highly versatile automated modular platforms.
- Integration of safety features like collaborative robots and adaptive scheduling software.
Main Results:
- Significant improvements in system flexibility achieved.
- Screening productivity maintained despite upgrades.
- Enhanced system accessibility and improved protocol design.
Conclusions:
- Advanced automation systems successfully address challenges in high throughput screening.
- Innovations support current needs and future strategies in drug discovery.
- Modular platforms enhance operational efficiency and adaptability.
