Related Experiment Video
Updated: Sep 29, 2025
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
Measurement Properties of Aerobic Capacity Measures in Neuromuscular Diseases: A Systematic Review
Tim Veneman1, Fieke Sophia Koopman2, Joost Daams3
1Amsterdam Universitair Medische Centra (UMC), University of Amsterdam, Department of Rehabilitation Medicine, Amsterdam Movement Sciences. t.veneman@amsterdamumc.nl.
Objective:
To systematically evaluate the measurement properties of aerobic capacity measures in neuromuscular diseases.
Data Sources:
MEDLINE, EMBASE, SportDiscus and Web of Science Conference Proceedings Citation Index - Science were systematically searched from inception until 30 June 2021.
Study Selection And Data Extraction:
Screening, data extraction, risk of bias assessment and quality assessment were performed by 2 independent researchers. Studies were included if they evaluated measurement properties of aerobic capacity measures in adults with neuromuscular diseases. Risk of bias was assessed using the COnsensus based Standards for the selection of health status Measurement INstruments (COSMIN) checklist. Results were pooled and the quality of the evidence was determined using a modified Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.
Data Synthesis:
Nine studies including 187 participants were included in this review. Low quality of evidence was found for sufficient content validity of peak oxygen consumption through maximal exercise testing. Criterion validity of 4 out of 7 different measures to predict peak oxygen consumption was sufficient; however, quality of evidence was low or very low for all measures. No studies were found evaluating reliability or responsiveness.
Conclusion:
There was a lack of high-quality studies with sufficiently large sample sizes that evaluated the measurement properties of aerobic capacity measures in neuromuscular diseases.
