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Related Experiment Videos

Somatomedins and steroids.

A Caufriez, G Copinschi

    Hormone Research
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Somatomedin activity decreases in hypercortisolism due to inhibitors, not low levels. Sex steroids like testosterone and estradiol influence somatomedin-C (Sm-C) production, with varying effects based on dose and age.

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    Area of Science:

    • Endocrinology
    • Hormone Research

    Background:

    • Somatomedin levels are typically normal in hypercortisolism.
    • Decreased somatomedin activity in hypercortisolism is attributed to elevated somatomedin inhibitors.
    • These inhibitors impede somatomedin action, rather than reflecting reduced production.

    Purpose of the Study:

    • To investigate the role of sex steroids in modulating somatomedin levels.
    • To explore the relationship between sex hormones and somatomedin-C (Sm-C) production.
    • To understand hormonal influences on somatomedin activity.

    Main Methods:

    • Radioreceptor assay, competitive protein-binding assay, and radioimmunoassay were used to measure somatomedin levels.
    • Analysis of somatomedin activity in the context of hypercortisolism.

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  • Correlation studies examining sex steroid levels (estradiol, testosterone) and Sm-C values.

    • Main Results:

    • Somatomedin levels remain normal in hypercortisolism, with reduced activity caused by inhibitors.
    • Progestagens may directly stimulate somatomedin-C production.
    • Pubertal increases in Sm-C correlate with estradiol and testosterone.
    • Low-dose estrogens and testosterone enhance Sm-C secretion in young individuals.
    • Adult women show a positive correlation between testosterone and Sm-C.
    • Higher estrogen doses or older age can inhibit Sm-C.

    Conclusions:

    • Somatomedin levels and activity are significantly modulated by variations in sex steroid levels.
    • The interplay between sex hormones and somatomedins is complex, influenced by age and dosage.
    • Understanding these interactions is crucial for endocrine research.