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Updated: Sep 29, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Scleral remodeling in myopia development.

Qi Yu1,2, Ji-Bo Zhou1,2

  • 1Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

International Journal of Ophthalmology
|March 21, 2022
PubMed
Summary
This summary is machine-generated.

Myopia, or nearsightedness, is a growing global health issue often caused by increased eye axial length. Scleral remodeling, involving changes to the eye

Keywords:
MMPs/TIMPsextracellular matrixhypoxia-inducible factor-1αmyopiascleral remodeling

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Cell Biology

Background:

  • Myopia is a significant global health concern with increasing prevalence.
  • Increased axial length of the eye is the primary structural cause of myopia.
  • Scleral remodeling, driven by extracellular matrix (ECM) changes, is linked to eye lengthening.

Purpose of the Study:

  • To review recent research on scleral remodeling in myopia.
  • To explore the role of scleral remodeling in myopia incidence and progression.
  • To offer new insights for myopia prophylaxis and treatment.

Main Methods:

  • Literature review of recent research progress.
  • Focus on studies investigating scleral remodeling mechanisms.
  • Analysis of the link between ECM changes and axial elongation.

Main Results:

  • Scleral remodeling is critically involved in myopia development.
  • Changes in the scleral extracellular matrix are key to eye lengthening.
  • Understanding scleral remodeling offers potential therapeutic targets.

Conclusions:

  • Scleral remodeling is a crucial factor in myopia.
  • Further research into scleral ECM is needed for myopia control.
  • This review provides a foundation for novel myopia prevention and treatment strategies.