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Coronavirus disease 2019 (COVID-19) as a potential trigger for benign recurrent intrahepatic cholestasis

Turan Çalhan1, Elif Yivli1

  • 1Department of Gastroenterology Haseki Training and Research Hospital Istanbul Turkey.

Clinical Case Reports
|March 21, 2022
PubMed

Insights

Benign recurrent intrahepatic cholestasis (BRIC), a rare liver condition causing itching and jaundice, can be triggered by COVID-19 infection. This case highlights the potential link between viral illness and BRIC exacerbation.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Rare Diseases

Background:

  • Benign recurrent intrahepatic cholestasis (BRIC) is a rare genetic disorder.
  • BRIC presents with recurrent episodes of severe cholestasis, itching, and jaundice.
  • Coronavirus disease 2019 (COVID-19) frequently impacts the liver.

Observation:

  • A case of BRIC is presented where symptoms were triggered by a COVID-19 infection.
  • The patient experienced severe itching and jaundice, characteristic of BRIC.

Findings:

  • COVID-19 infection can act as a trigger for episodes of benign recurrent intrahepatic cholestasis.
  • This association suggests a potential interplay between viral infections and cholestatic liver diseases.

Implications:

  • Understanding triggers for BRIC is crucial for patient management.
  • Further research may elucidate mechanisms linking viral infections to cholestasis.

Keywords:
benign recurrent intrahepatic cholestasiscoronavirus disease 2019liver

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