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Parental understanding and attitudes following pharmacogenomic testing for pediatric neuropsychiatric patients

Courtney Berrios1,2, Sophia K Sadaro1, Tracy Sandritter3,4

  • 1Genomic Medicine Center, Children's Mercy, Kansas City, MO 64108, USA.

Pharmacogenomics
|March 21, 2022
PubMed

Insights

Parents find pharmacogenomic testing useful for their children, but understanding complex results, especially those indicating normal drug metabolism, presents challenges. Accurate interpretation is key for effective treatment guidance.

Area of Science:

  • Pharmacogenomics
  • Pediatric neuropsychiatry
  • Genetics

Background:

  • Pharmacogenomic testing is increasingly used in pediatric neuropsychiatry.
  • Parental understanding is crucial for the effective integration of pharmacogenomic data into clinical practice.
  • Limited research exists on parental comprehension of pharmacogenomic results for their children.

Purpose of the Study:

  • To explore parental understanding and attitudes towards pharmacogenomic testing results in children.
  • To identify factors influencing parental comprehension of pharmacogenomic information.
  • To assess the perceived utility of pharmacogenomic results by parents.

Main Methods:

  • Qualitative study involving in-depth interviews with 18 parents.
  • Parents were those whose children underwent pharmacogenomic testing for neuropsychiatric medication management.
  • Interviews were thematically analyzed for accuracy of understanding and key themes.

Main Results:

  • 78% of parental statements regarding pharmacogenomic results were accurate.
  • Understanding varied based on clinic, number of medications, and result type.
  • Parents valued results that could guide current prescribing decisions.
  • Results indicating normal drug metabolism elicited mixed parental feelings.

Conclusions:

  • Parents recognize the utility of pharmacogenomic testing for pediatric care.
  • Challenges remain in parental comprehension of probabilistic and multifactorial pharmacogenomic information.
  • Further education and clear communication strategies are needed to enhance parental understanding.

Keywords:
attitudesexpectationsneuropsychiatric medicationsparentpediatricpharmacogenomicsunderstanding

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