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Nectin-4: a Novel Therapeutic Target for Skin Cancers

Hiroki Hashimoto1, Yuka Tanaka2, Maho Murata2

  • 1Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. h-hashi@dermatol.med.kyushu-u.ac.jp.

Current Treatment Options in Oncology
|March 21, 2022
PubMed
Abstract

Insights

Nectin-4, a protein found on cancer cells, is a promising target for new treatments. Therapies targeting Nectin-4, like antibody-drug conjugates (ADCs), show potential for treating various skin cancers.

Area of Science:

  • Oncology
  • Immunotherapy
  • Molecular Biology

Background:

  • Nectin-4 is a tumor-associated antigen highly expressed on various cancer cells.
  • Nectin-4 plays roles in tumor development, proliferation, motility, and invasion.
  • Nectin-4 blockade can reduce tumor proliferation and induce apoptosis.

Purpose of the Study:

  • To review current knowledge on Nectin-4 in malignant tumors.
  • To highlight the efficacy of enfortumab vedotin (an ADC targeting Nectin-4) in clinical trials.
  • To explore the prospects of Nectin-4-targeted agents against skin cancers.

Main Methods:

  • Review of existing literature on Nectin-4 and its role in cancer.
  • Analysis of clinical trial data for enfortumab vedotin.
  • Examination of preclinical studies on Nectin-4-targeted therapies.

Main Results:

  • Nectin-4 is highly expressed in skin cancers like melanoma and squamous cell carcinoma.
  • Enfortumab vedotin, an ADC targeting Nectin-4, is approved for urothelial cancer and shows efficacy in other solid tumors.
  • Preclinical studies and ongoing clinical trials support Nectin-4 as a therapeutic target.

Conclusions:

  • Nectin-4 is a viable therapeutic target for various malignancies, including skin cancers.
  • Nectin-4-targeted therapies, particularly ADCs like enfortumab vedotin, represent novel treatment options.
  • Further research and clinical trials are warranted to establish Nectin-4-targeted agents for skin cancer treatment.
Keywords:
Antibody-drug conjugateEnfortumab vedotinNectin-4PVRL4Skin cancerTargeted therapy

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