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Related Concept Videos

Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding01:22

Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding

308
When a drug follows nonlinear pharmacokinetics, its bioavailability, the amount of the drug that reaches the systemic circulation, can change with different doses. This is due to the presence of a saturable pathway. The pathway becomes saturated as the drug concentration increases, decreasing the absorption rate. Consequently, the drug's bioavailability may be lower than expected at higher doses.
To quantify the extent of bioavailability, pharmacologists often use a parameter called .
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Related Experiment Video

Updated: Sep 29, 2025

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
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Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

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Nanoparticle and bioparticle deposition kinetics.

Zbigniew Adamczyk1, Maria Morga1, Małgorzata Nattich-Rak1

  • 1Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Niezapominajek 8, 30-239 Krakow, Poland.

Advances in Colloid and Interface Science
|March 21, 2022
PubMed
Summary
This summary is machine-generated.

Particle deposition kinetics at solid surfaces were reviewed, covering theoretical models and experimental data. Findings suggest simple colloid particle behavior can predict complex bioparticle deposition, highlighting universal principles in self-assembled layer formation.

Keywords:
Corona formation of nanoparticlesDeposition of particlesElectrokintic measurementsGold nanoparticlesKinetics of particle depositionMechanisms of depositionModeling of particle depositionNanoparticle depositionNanoparticle layersQuartz microbalance measurementsSilica nanoparticlesSilver particle depositionSilver particle release kineticsVirus attachementZeta potential of nanoparticles

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Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
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Area of Science:

  • Surface Science
  • Colloid Science
  • Nanotechnology

Background:

  • Particle deposition is crucial for self-assembled layer formation.
  • Understanding deposition kinetics is key for controlling layer structure and density.

Purpose of the Study:

  • To review theoretical and experimental aspects of particle deposition kinetics.
  • To analyze nanoparticle and microparticle deposition mechanisms.
  • To discuss the applicability of various methods for studying deposition.

Main Methods:

  • Theoretical analysis of linear and non-linear transport regimes.
  • Experimental studies on micro- and nanoparticles, including silver particles.
  • Quartz crystal microbalance (QCM) measurements.
  • Nanoparticle corona formation studies using concentration depletion, AFM, SEM, and in situ electrokinetic methods.

Main Results:

  • Calculated monolayer formation times for nanoparticles under diffusion and flow.
  • Analyzed layer stability and release kinetics for silver particles.
  • Demonstrated the utility of QCM for quantitative kinetic studies.
  • Investigated nanoparticle corona formation on polymer carriers.

Conclusions:

  • Theoretical models provide insights into linear and non-linear deposition regimes.
  • Experimental results validate theoretical predictions and highlight layer stability.
  • QCM is a valuable tool for quantitative deposition kinetics.
  • Colloid particle deposition behavior serves as a universal reference for bioparticle deposition.