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Updated: Sep 29, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Effects of heat strain on cognitive function among a sample of miners
Kristin Yeoman1, Alyssa Weakley2, Weston DuBose1
1National Institute for Occupational Safety and Health, 315 E. Montgomery Ave, Spokane, WA, 99207, USA.
Abstract:
Heat stress is associated with workplace injuries, likely through a combination of fatigue, reduced cognitive function, and thermal discomfort. The purpose of this study was to evaluate four cognitive tasks for sensitivity to heat stress. Eight participants performed treadmill exercise followed by assessments of serial reaction time (RT), Stroop effect, verbal delayed memory, and continuous performance working memory in an environmental chamber. A control (21.1 °C) trial, and "Hot 1" and "Hot 2" (both 37.8 °C) trials were run sequentially on two separate days to evaluate the four cognitive tasks. Heat strain (comparing Hot 1 and Hot 2 with the control trial) resulted in impairments in the serial RT test response and Stroop accuracy. Delayed memory was impacted only in the Hot 2 trial compared with the control trial. Given the demonstrated impact of heat on cognitive processes relevant to workers' real-world functioning in the workplace, understanding how to assess and monitor vigilant attention in the workplace is essential.
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