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Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Nursing Clinical Information System (NCIS)
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Updated: Sep 29, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Multisystem Inflammatory Syndrome in Children (MIS-C).

Julisa M Patel1

  • 1Allergy-Immunology and Pediatric Rheumatology Division, Department of Pediatrics, Children's Hospital of Georgia, Augusta University Medical Center, 1120 15th Street, BG 102, Augusta, GA, 30912, USA. jupatel1@augusta.edu.

Current Allergy and Asthma Reports
|March 22, 2022
PubMed
Summary
This summary is machine-generated.

Multisystem inflammatory syndrome in children (MIS-C) is a rare post-infectious complication of COVID-19. Prompt diagnosis and treatment with IVIG and steroids improve outcomes, with most children recovering fully.

Keywords:
COVID-19Multisystem inflammatory syndrome in children (MIS-C)Pediatric inflammatory multisystem syndromeSARS-COV-2

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Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Cardiology

Background:

  • COVID-19 pandemic has led to the emergence of MIS-C, a rare hyperinflammatory condition in children.
  • MIS-C shares features with Kawasaki disease, MAS, and TSS, presenting a diagnostic challenge.
  • Characterized by systemic inflammation, fever, hypotension, and cardiac dysfunction.

Purpose of the Study:

  • To review the clinical presentation, immunopathogenesis, management, and outcomes of MIS-C.
  • To provide clinicians with an overview for high clinical suspicion and prompt diagnosis.
  • To highlight the evolving understanding and importance of timely intervention.

Main Methods:

  • Review of current literature on MIS-C.
  • Analysis of presenting features, overlapping syndromes, and proposed pathogenesis.
  • Summary of recommended treatments and patient outcomes.

Main Results:

  • MIS-C presents with diverse symptoms including fever, GI issues, and cardiac complications like myocarditis and aneurysms.
  • Younger children may show Kawasaki-like features; older children can present with cardiogenic shock.
  • Intravenous immunoglobulins and glucocorticoids are first-line treatments; biologics for refractory cases.

Conclusions:

  • Most MIS-C patients recover with treatment, showing resolution of inflammation and cardiac issues.
  • Mortality is rare, emphasizing the importance of early recognition and management.
  • High clinical suspicion in children with recent COVID-19 exposure and inflammatory signs is crucial.