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Updated: Sep 29, 2025
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Prognostic value of 18F-FDG PET/CT in malignant pleural mesothelioma: a meta-analysis
Yu Wang1, Yanfeng Xu1, Ying Kan1
1Department of Nuclear Medicine, 26455Beijing Friendship Hospital of Capital Medical University, Beijing, PR China.
Background:
Several FDG PET/CT parameters have been utilized to evaluate the prognosis in malignant pleural mesothelioma (MPM). However, there are still controversial results due to the low incidence of MPM.
Purpose:
To assess the prognostic value of 18F-FDG PET/CT in MPM.
Material And Methods:
A systematic literature search was performed in PubMed, Embase, Medline, and The Cochrane Library to identify eligible studies from inception to 12 February 2020. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of several variables, such as maximum standardized uptake value (SUVmax), the reduction of SUVmax after treatment (ΔSUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and the reduction of TLG after treatment (ΔTLG), were calculated. Meta-regression with subsequent subgroup analyses were conducted to determine the heterogeneity of cutoff values, treatment regimen, study design, uptake time, and scanners across various studies.
Results:
In total, 19 eligible studies including 1819 patients were enrolled in the meta-analysis. The univariate analysis showed that the pooled HRs (95% CI) of SUVmax, ΔSUVmax, MTV, TLG, and ΔTLG were 1.29 (1.16-1.42), 1.12 (1.05-1.19), 1.15 (1.00-1.33), 1.47 (1.23-1.76), and 1.27 (1.12-1.45), respectively. The multivariate analysis showed that the pooled HRs (95% CI) of SUVmax, ΔSUVmax, MTV, and TLG for overall survival (OS) were 1.20 (1.08-1.33), 1.10 (1.02-1.19), 0.95 (0.81-1.11), and 1.13 (1.08-1.18), respectively.
Conclusion:
SUVmax, ΔSUVmax, TLG, and ΔTLG are significant prognostic indicators for OS, while more clinical studies are needed to confirm the prognostic value of MTV in MPM.
Insights
18F-FDG PET/CT parameters like SUVmax and TLG are significant prognostic indicators for overall survival in malignant pleural mesothelioma (MPM). Further research is needed to confirm the prognostic value of metabolic tumor volume (MTV).
Area of Science:
- Oncology
- Radiology
- Nuclear Medicine
Background:
- Malignant pleural mesothelioma (MPM) prognosis evaluation often uses FDG PET/CT parameters.
- Controversial results exist due to MPM's low incidence.
Approach:
- Systematic literature search in PubMed, Embase, Medline, and Cochrane Library up to February 12, 2020.
- Meta-analysis calculated pooled hazard ratios (HRs) for SUVmax, ΔSUVmax, MTV, TLG, and ΔTLG.
- Meta-regression and subgroup analyses explored heterogeneity factors.
Key Points:
- 19 studies with 1819 patients were included.
- Univariate analysis: SUVmax (HR 1.29), ΔSUVmax (HR 1.12), MTV (HR 1.15), TLG (HR 1.47), ΔTLG (HR 1.27) were significant.
- Multivariate analysis: SUVmax (HR 1.20), ΔSUVmax (HR 1.10), TLG (HR 1.13) were significant for overall survival (OS).
Conclusions:
- SUVmax, ΔSUVmax, TLG, and ΔTLG are significant prognostic indicators for OS in MPM.
- The prognostic value of MTV requires further clinical investigation.
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