Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

16.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
16.1K
Complement System01:27

Complement System

3.0K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Fried Frailty Phenotype With Occlusal Status, Health-Related Quality of Life, and Nutritional Status Among Older Adults Living in Long-Term Care.

Journal of oral rehabilitation·2026
Same author

Acute non-alcoholic caffeinated beverage consumption as a trigger for cryptogenic ischemic stroke in the young: findings from the SECRETO study.

Journal of neurology·2026
Same author

Periodontitis and Endotoxemia: Clinical and Microbiological Insights.

Journal of clinical periodontology·2026
Same author

Association Between Physical Activity and Cryptogenic Ischemic Stroke in Young Adults: A Case-Control Study.

European journal of neurology·2026
Same author

Microbial burden of periodontal diseases and its clinical application: The stage, grade, and furcation matter.

Journal of periodontology·2026
Same author

Risk Haplotype of BTNL2 Predisposes Male Patients to NSTEMI: A Genetic and Functional Study.

Research square·2026

Related Experiment Video

Updated: Sep 29, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.4K

Common complement factor H polymorphisms are linked with periodontitis in elderly patients.

Aino Salminen1, Milla Pietiäinen1, Susanna Paju1

  • 1Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Journal of Periodontology
|March 22, 2022
PubMed
Summary
This summary is machine-generated.

Genetic variants in the complement factor H (CFH) gene are linked to periodontitis. Salivary levels of S100A8, S100A12, MMP-8, and TCC correlate with periodontitis severity, not specific gene polymorphisms.

Keywords:
geneticsinflammationperiodontitissaliva

More Related Videos

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.7K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K

Related Experiment Videos

Last Updated: Sep 29, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.4K
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.7K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K

Area of Science:

  • Genetics
  • Immunology
  • Periodontology

Background:

  • Genetic polymorphisms in complement factor H (CFH) and S100A gene regions associate with serum matrix metalloproteinase 8 (MMP-8) levels.
  • MMP-8 is crucial in periodontitis pathogenesis.

Purpose of the Study:

  • Evaluate genetic polymorphisms in S100A8/A9/A12, MMP8, and CFH in periodontitis.
  • Determine if these polymorphisms affect salivary concentrations of S100A8, S100A12, MMP-8, or complement activation markers.

Main Methods:

  • Genotyped four single-nucleotide polymorphisms (SNPs) in S100A8/A9/A12, MMP8, and CFH genes in 508 individuals from the Parogene cohort.
  • Measured salivary concentrations of S100A8, S100A12, MMP-8, and terminal complement complex (TCC).

Main Results:

  • CFH polymorphisms (rs800292, rs1061170) associated with periodontal parameters.
  • No polymorphisms correlated with salivary protein levels.
  • Salivary S100A8, S100A12, MMP-8, and TCC levels strongly associated with periodontal pocket number and alveolar bone loss.

Conclusions:

  • CFH, MMP8, and S100A8/A9/A12 genetic variants did not influence salivary protein levels.
  • Salivary levels of S100A8, S100A12, MMP-8, TCC, and CFH polymorphisms are linked to periodontitis clinical and radiographic signs.
  • Complement dysregulation may heighten the risk for inflammatory disorders like periodontitis.