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Serum Heat Shock Protein 70 Level in Children with Attention Deficiency Hyperactivity Disorder
Ahmet Özaslan1, Esra Güney1, Özlem Gülbahar2
1Child and Adolescent Psychiatry Department, Gazi University Medical Faculty, Ankara, Turkey.
Insights
Children with attention deficit hyperactivity disorder (ADHD) have lower serum heat shock protein 70 (HSP70) levels. This finding suggests HSP70 may play a role in ADHD pathophysiology and could offer diagnostic potential.
Area of Science:
- Neuroscience
- Immunology
- Genetics
Background:
- Attention deficit hyperactivity disorder (ADHD) has a complex etiology.
- Current research explores the link between ADHD, immune function, and oxidative stress.
- Heat shock proteins (HSPs) are involved in cellular protection and stress response.
Purpose of the Study:
- To investigate the potential role of heat shock protein 70 (HSP70) in the pathophysiology of ADHD.
- To compare serum HSP70 levels in children with ADHD and typically developing children.
Main Methods:
- Study included 41 children diagnosed with ADHD and 32 typically developing controls.
- ADHD presentation and severity were assessed using the Conners' Teacher Rating Scale (CTRS).
- Serum HSP70 levels were quantified using an enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Children with ADHD exhibited significantly lower serum HSP70 levels compared to controls (p<0.01).
- No significant correlation was found between HSP70 levels and ADHD severity or presentation type (p>0.05).
Conclusions:
- Lower serum HSP70 levels suggest a potential role in ADHD etiological mechanisms.
- Peripheral HSP70 changes may hold diagnostic or therapeutic value for ADHD.
- Further prospective research is required to elucidate the precise relationship between HSP70 and ADHD.
Introduction:
Attention deficit hyperactivity disorder (ADHD) have quite complicated etiology. The relationship between ADHD and immune and oxidative imbalances is discussed in current researches investigating the pathophysiology of ADHD. The aim of the study is to determine whether heat shock protein 70 (HSP70) has a potential role in pathophysiologic mechanisms of attention deficit hyperactivity disorder.
Methods:
This study included 41 children that were diagnosed with ADHD and 32 typically developing children. Conners' Teacher Rating Scale (CTRS) was used to evaluate ADHD presentation and severity. Additionally, an enzyme-linked immunosorbent assay (ELISA) kit was used to evaluate serum HSP70 level.
Results:
We have detected that the serum HSP70 levels of children with ADHD were lower than the typically developing group (p<0.01). No relationship was determined between HSP70 levels and either the severity of ADHD or predominantly ADHD presentations (p>0.05).
Conclusion:
With these findings, it can be proposed that HSP70 might have a crucial role in the etiological mechanisms of ADHD. Moreover, these changes in peripheral blood may have therapeutic and/or diagnostic value. However, more detailed prospective studies are needed to explain the link between ADHD and heat shock proteins.
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