Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

39.4K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
39.4K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

145
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
145
Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding01:22

Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding

308
When a drug follows nonlinear pharmacokinetics, its bioavailability, the amount of the drug that reaches the systemic circulation, can change with different doses. This is due to the presence of a saturable pathway. The pathway becomes saturated as the drug concentration increases, decreasing the absorption rate. Consequently, the drug's bioavailability may be lower than expected at higher doses.
To quantify the extent of bioavailability, pharmacologists often use a parameter called .
308
Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

4.9K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.9K
Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

Nonlinear Pharmacokinetics: Causes of Nonlinearity

371
Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
371

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of SCN1A and SCN2A Gene Polymorphisms with Antiseizure Medication Responsiveness: A Case-Control Study from Eastern India.

Annals of Indian Academy of Neurology·2026
Same author

Lower-limb prosthetic mechanisms: recent progress, control innovations and barriers to real-world adoption.

Biomedical engineering online·2026
Same author

Controlling complex rhythms: A hierarchical approach to limit cycle switching.

Chaos (Woodbury, N.Y.)·2025
Same author

A Linear Mn<sub>3</sub> Molecular Cluster as a Bifunctional Electrocatalyst for Overall Water Splitting.

Inorganic chemistry·2025
Same author

In Situ Synthesis of Luminescent CdSe Quantum Dots Embedded in Cd(II) Metallohydrogels: A Hybrid Material for Selective and Naked-Eye Sensing of Hg<sub>2</sub><sup>2+</sup> Ions.

Inorganic chemistry·2025
Same author

Nonlinear stochastic differential equations: A renormalization group approach to direct calculation of moments.

Physical review. E·2025
Same journal

Hypercholesterolemia-induced impairment in sorafenib functionality is overcome by avasimibe co-treatment.

Journal of biosciences·2026
Same journal

Evolutionary trade-offs in plant immunity: prioritizing antiviral priming by herbivore-induced plant volatiles over defense against herbivores.

Journal of biosciences·2026
Same journal

Birds and bees do not express RAGE: comparative physiology and non-conventional model organisms hold the key to hyperglycemia tolerance.

Journal of biosciences·2026
Same journal

Distinct macrophage and microglia function in ischemic stroke.

Journal of biosciences·2026
Same journal

Dynamic attributes of the pedicel: Key drivers, structure and function in angiosperms.

Journal of biosciences·2026
Same journal

Cardiometabolomic signatures and gut microbiota dynamics in perinatally undernourished F<sub>1</sub> offspring: Decoding the metabolic footprint.

Journal of biosciences·2026
See all related articles

Related Experiment Video

Updated: Sep 29, 2025

Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems
05:44

Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems

Published on: February 16, 2024

1.3K

Universality in bio-rhythms: A perspective from nonlinear dynamics.

Sandip Saha1, Gautam Gangopadhyay, Deb Shankar Ray

  • 1S N Bose National Centre For Basic Sciences, Block-JD, Sector-III, Salt Lake, Kolkata 700106, India.

Journal of Biosciences
|March 23, 2022
PubMed
Summary
This summary is machine-generated.

Bio-rhythms, arising from oscillating biochemical reactions, can be universally described by the Lie´nard equation. This mathematical model reveals both single and dual rhythmic patterns in biological systems.

More Related Videos

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

10.0K
Bouncing Ball with a Uniformly Varying Velocity in a Metronome Synchronization Task
05:04

Bouncing Ball with a Uniformly Varying Velocity in a Metronome Synchronization Task

Published on: September 21, 2017

6.1K

Related Experiment Videos

Last Updated: Sep 29, 2025

Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems
05:44

Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems

Published on: February 16, 2024

1.3K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

10.0K
Bouncing Ball with a Uniformly Varying Velocity in a Metronome Synchronization Task
05:04

Bouncing Ball with a Uniformly Varying Velocity in a Metronome Synchronization Task

Published on: September 21, 2017

6.1K

Area of Science:

  • Biochemistry
  • Systems Biology
  • Theoretical Biology

Background:

  • Bio-rhythms are fundamental to all living organisms, originating from complex biochemical reaction networks.
  • These oscillations occur in open, thermodynamically active systems with autocatalysis and feedback mechanisms.
  • Minimal kinetic models with two state variables are often used to describe these biological rhythms.

Purpose of the Study:

  • To demonstrate the universality of mathematical models describing bio-rhythms.
  • To show that diverse bio-chemical processes can be mapped to a common kinetic equation.
  • To explore the mono-rhythmic and bi-rhythmic solutions admitted by this universal equation.

Main Methods:

  • Analysis of bio-kinetic schemes and their underlying biochemical and biophysical processes.
  • Mapping kinetic equations of bio-rhythms to the universal form of the Lie´nard equation.
  • Examination of specific examples to illustrate the universality of the model.

Main Results:

  • The kinetic equations governing diverse bio-rhythms can be universally mapped to the Lie´nard equation.
  • The Lie´nard equation framework successfully describes both mono-rhythmic and bi-rhythmic biological oscillations.
  • The study validates a unified mathematical approach for understanding various bio-rhythmic phenomena.

Conclusions:

  • A universal mathematical framework, based on the Lie´nard equation, effectively describes bio-rhythms across different biological systems.
  • This universality simplifies the study of complex biological oscillations, irrespective of their specific biochemical underpinnings.
  • The findings provide insights into the fundamental principles governing biological rhythmicity.