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miRNAs in SARS-CoV-2 Infection: An Update
Asim Azhar1, Wajihul Hasan Khan2,3, Khaled Al-Hosaini4
1Aligarh College of Education, Aligarh, UP, India.
Current Drug Metabolism
|March 23, 2022
Summary
This review explores microRNAs (miRNAs) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It highlights miRNAs
Area of Science:
- Molecular Biology
- Virology
- Genetics
Background:
- Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
- While SARS-CoV-2's role in COVID-19 is studied, the involvement of microRNAs (miRNAs) remains unclear.
- microRNAs are crucial regulators of biological processes including immunity and infection.
Purpose of the Study:
- To provide a comprehensive overview of the role of miRNAs in SARS-CoV-2 infection.
- To summarize recent findings on miRNAs associated with SARS-CoV-2.
- To discuss the multifaceted roles of miRNAs in viral infections and potential therapeutic applications.
Main Methods:
- Literature review of recent findings on miRNAs and SARS-CoV-2 infection.
- Analysis of the functions of miRNAs in viral pathogenesis.
- Discussion of miRNA expression, biomarker potential, and therapeutic strategies.
Main Results:
- microRNAs are implicated in SARS-CoV-2 infection, influencing host-pathogen interactions.
- miRNAs are found in cellular receptors and their expression is altered in various diseases.
- Potential roles of miRNAs as biomarkers and therapeutic targets for COVID-19 are discussed.
Conclusions:
- microRNAs play significant roles in the biological processes affected by SARS-CoV-2.
- Further research is needed to fully elucidate the mechanisms of miRNA involvement in COVID-19.
- miRNAs hold promise as diagnostic biomarkers and therapeutic agents against SARS-CoV-2.
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