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Updated: Sep 29, 2025

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Burkitt Lymphoma After Cardiac Transplantation: Therapeutic Considerations
Batool El-Atoum1, Margaret Williams2, Kimberly Molina3
1Department of Pediatrics, Division of Hematology/Oncology.
Abstract:
Postsolid organ transplant Burkitt lymphoma (PSOT-BL) is rare but more aggressive than other post-transplant lymphoproliferative disorders (PTLD). Little is known about optimal treatment and outcome of postcardiac transplant Burkitt lymphoma (BL). We report an 8-year-old boy with a history of heart transplant who developed Epstein-Barr virus positive, late-onset PSOT-BL. He was successfully treated with BL specific chemoimmunotherapy and cessation of baseline immunosuppression. In this pediatric case of PSOT-BL, the use of standard intensive pediatric based chemoimmunotherapy regimen without modifications was feasible, well tolerated and resulted in complete remission. Long-term toxicities need further study.
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