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[Mortality in patients hospitalized with COVID-19 in northern Peru]
Franco León-Jiménez1, Camila Vives-Kufoy2, Virgilio E Failoc-Rojas3
1Departamento Medicina Interna, Hospital Santa Rosa Piura, Piura, Perú.
Insights
In Peru, over half of moderate to severe COVID-19 patients studied died. Older age, rapid disease progression, comorbidities, and specific lab results like neutrophilia were linked to higher mortality risks.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Public Health
Background:
- Peru faced exceptionally high COVID-19 mortality rates globally.
- Understanding risk factors for severe COVID-19 is crucial for patient outcomes.
Purpose of the Study:
- To detail the clinical presentation and progression of COVID-19 in Peruvian patients.
- To identify factors associated with mortality in moderate to severe COVID-19 cases.
Main Methods:
- A prospective analytical study was conducted.
- Clinical, laboratory, imaging, and mortality data were collected from 391 hospitalized patients.
- Data was gathered over a two-month period during the initial pandemic wave.
Main Results:
- The median age of patients was 60 years, with 70% being women.
- Common findings included neutrophilia (78%) and ground-glass opacities on imaging (91%).
- A high mortality rate of 53% was observed, with 50% of all patients dying.
Conclusions:
- Mortality in this cohort was substantial, with over half of the patients succumbing to the disease.
- Key factors associated with increased mortality included advanced age, rapid disease progression, presence of comorbidities, lymphopenia, neutrophilia, and a low PaO2/FiO2 ratio.
Background:
Peru has one of the highest mortality rates due to COVID-19 in the world.
Aim:
To describe the clinical features, evolution and explore factors associated with mortality in patients with moderate to severe Covid-19.
Material And Methods:
Prospective analytical study. The clinical, laboratory, imaging, and mortality data of patients admitted at a COVID service of the Santa Rosa de Piura Hospital were recorded from April to June 2020.
Results:
Data from 391 patients with a median age of 60 years (70% women) was gathered. The time lapse between the onset of the disease and hospitalization was seven days. The most common alteration in the blood count was Neutrophilia in 78% of patients. The median PaO2/FiO2 ratio was 77. The distribution of tomographic patterns was Ground glass in 91% of patients, interstitial involvement in 57%, consolidation in 43%. Sixteen percent of patients had at least one complication, the most common was an increase in transaminases in 2%. Four percent were admitted to the intensive care unit and 53% died (94% during hospitalization and 5.8% during ICU stay). In the bivariate analysis, an association was found between a higher mortality and older age (p = 0.01), having fewer days of illness (p = 0.03), fewer days of hospital stay (p < 0.01), having at least one comorbidity (p = 0.02), lymphopenia (p = 0.02), neutrophilia (P = 0.03) and lower PaO2/ FiO2 ratio (p < 0.01).
Conclusions:
Fifty percent of these patients died. Age, rapid progression, having comorbidities and other laboratory alterations were associated with mortality.
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