Primer on Mathematical Modeling in C. elegans

Recently, applications of mathematical and computational models to biological processes have helped investigators to systematically interpret data, test hypotheses built on experimental data, generate new hypotheses, and guide the design of new experiments, protocols, and synthetic biological systems. Availability of diverse quantitative data is a prerequisite for successful mathematical modeling. The ability to acquire high-quality quantitative data for a broad range of biological processes and perform precise perturbation makes C. elegans an ideal model system for such studies. In this primer, we examine the general procedure of modeling biological systems and demonstrate this process using the heat-shock response in C. elegans as a case study. Our goal is to facilitate the initial discussion between worm biologists and their potential collaborators from quantitative disciplines.