Public attitudes to a human challenge study with SARS-CoV-2: a mixed-methods study.

Area of Science:

• Infectious disease research
• Vaccinology
• Public health

Background:

• Human challenge studies deliberately expose volunteers to pathogens for disease research and vaccine development.
• The UK explored SARS-CoV-2 (COVID-19) challenge studies in 2020, necessitating public input due to ethical complexities and public interest.
• Public engagement is crucial for accountability and informed consent in high-stakes research.

Purpose of the Study:

• To explore UK public attitudes towards a potential SARS-CoV-2 human challenge study.
• To identify public concerns and practical considerations for designing such studies.
• To inform ethical review and study protocols by incorporating public perspectives.

Main Methods:

• A mixed-methods approach was employed, combining online surveys with 2,441 UK adults and virtual focus groups with 57 UK adults.
• Data collection occurred in October 2020 to capture timely public sentiment.
• The study focused on attitudes, perceived risks, and practical barriers to participation.

Main Results:

• Broad public agreement supported conducting SARS-CoV-2 challenge studies in the UK.
• Key concerns included transparency, trust, clear risk communication, long-term health effects, and isolation.
• Practical factors like Wi-Fi, exercise access, and personal/family commitments significantly influenced potential participation.

Conclusions:

• The study identified essential practical considerations for designing human challenge studies.
• Recommendations focus on participant messaging, protocol review, and enhancing study inclusivity and relevance.
• Public consultation is invaluable for research in areas of significant public interest and scrutiny.